Table 5 Independent neuropathological assessments of illustrative case
From: COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)
ADNC | CTE-NC | α-synuclein | TDP-43 | ARTAG | CAA | CVD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | C | ADNC | Absent/present | Stage | Absent/present | Stage | Absent/present | Absent/present | Absent/present | Severity | |
Pathologist 01 | 3 | 3 | 3 | High | Absent | NA | Present | Diffuse neocortical | Present | Present | Present | Moderate |
Pathologist 02 | 3 | 2 | 3 | Inter | Absent | NA | Present | Cortex and brainstem | Present | Absent | Absent | None |
Pathologist 03 | 2 | 2 | 3 | Inter | Absent | NA | Present | Neocortical | Absent | Present | Absent | None |
Pathologist 04 | 3 | 3 | 3 | High | Absent | NA | Present | Amygdala/cortical/brainstem | Present | Absent | Absent | None |
Pathologist 05 | 2 | 3 | 3 | Inter | Absent | NA | Present | Neocortical | Present | Present | Present | Mild |
Pathologist 06 | 2 | 3 | 2 | Inter | Absent | NA | Present | Neocortical | Present | Present | Absent | None |
Pathologist 07 | 3 | 3 | 3 | High | Absent | NA | Present | Neocortical | Present | Present | Present | Mild |
Pathologist 08 | 3 | 2 | 3 | Inter | ? | ? | Present | Neocortical | Present | Absent | Absent | Mild |
Pathologist 09 | 3 | 3 | 3 | High | Absent | NA | Present | Neocortical | Present | Present | Present | NA |
Pathologist 10 | 3 | 3 | 3 | High | Absent | NA | Present | Neocortical | Present | Present | Present | Mild |
Consensus opinion | 2* | 3 | 3 | Inter | Absent | NA | Present | Neocortical | Present | Present | Present | None/mild |