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Table 5 Independent neuropathological assessments of illustrative case

From: COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)

  ADNC CTE-NC α-synuclein TDP-43 ARTAG CAA CVD
A B C ADNC Absent/present Stage Absent/present Stage Absent/present Absent/present Absent/present Severity
Pathologist 01 3 3 3 High Absent NA Present Diffuse neocortical Present Present Present Moderate
Pathologist 02 3 2 3 Inter Absent NA Present Cortex and brainstem Present Absent Absent None
Pathologist 03 2 2 3 Inter Absent NA Present Neocortical Absent Present Absent None
Pathologist 04 3 3 3 High Absent NA Present Amygdala/cortical/brainstem Present Absent Absent None
Pathologist 05 2 3 3 Inter Absent NA Present Neocortical Present Present Present Mild
Pathologist 06 2 3 2 Inter Absent NA Present Neocortical Present Present Absent None
Pathologist 07 3 3 3 High Absent NA Present Neocortical Present Present Present Mild
Pathologist 08 3 2 3 Inter ? ? Present Neocortical Present Absent Absent Mild
Pathologist 09 3 3 3 High Absent NA Present Neocortical Present Present Present NA
Pathologist 10 3 3 3 High Absent NA Present Neocortical Present Present Present Mild
Consensus opinion 2* 3 3 Inter Absent NA Present Neocortical Present Present Present None/mild
  1. ADNC Alzheimer’s disease neuropathologic changes, ARTAG aging-related tau astrogliopathy, CAA cerebral amyloid angiopathy, CTE-NC chronic traumatic encephalopathy neuropathologic change, CVD cerebrovascular disease, Inter intermediate, NA not applicable