Table 2 CNVs and mutations in molecular groups of CNS-PNET
Molecular alterations | CNS_NBL (20) | GBM_G34 (22) | GBM_MYCN (18) | EPN_RELA (24) |
|---|---|---|---|---|
MYCN amplifications | 0 | 0 | 70% | 0 |
PDGFRA amplification | 0 | 30% | 0 | 0 |
CCND2 amplification | 0 | 20% | 0 | 0 |
1q gain | 100% | 40% | 50% | 30% |
2p gain | 20% | 10% | 70% | 10% |
3p loss | 60% | 10% | 10% | 0 |
3q loss | 0 | 70% | 10% | 0 |
4q loss | 10% | 70% | 10% | 10% |
6q loss | 40% | 0 | 5% | 10% |
9p loss | 0 | 40% | 10% | 45% |
10q loss | 30% | 70% | 50% | 30% |
16q loss | 70% | 20% | 10% | 0 |
17p loss | 0 | 10% | 50% | 0 |
17q gain | 60% | 30% | 5% | 5% |
22q loss | 0 | 15% | 15% | 30% |
Recurrent mutations | No | G34V/R—22/22 | TP53—13/18 | No |
Recurrent fusions (54) | FOXR2—14/14 | No | NBAS—3/12 | RELA—20/20 |