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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

Fig. 3

a. A set of 30 top most-confident genes differentially overexpressed in CNS_NBL (blue top line); GBM_G34 (brown top line), GBM_MYCN (orange top line), and EPN_RELA (red top line) respectively allows one to discriminate clearly between these tumor cohorts with SOX10 among the top genes for CNS_NBL (Row Z-Scores: green: from 0 to − 6; red: from 0 to 6). b. FOXR2 and SOX10 expression levels were significantly higher in CNS_NBL (blue boxplots) whereas MYCN was overexpressed in GBM_MYCN (orange boxplots) and RELA—EPN_RELA (red boxplots) respectively. c. Gene Ontology analysis disclosed that CNS_NBL transcriptome signatures (blue circles) were associated with neuronal metabolism, synaptic transmission, and neuroendocrine secretion

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Acta Neuropathologica Communications

ISSN: 2051-5960

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