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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

Fig. 1

a. Pathological similarity of CNS-PNET samples allocated to various molecular groups (The scale bars: 50 μm). b. Two-dimensional t-distributed stochastic neighbor embedding (tSNE) analysis of reference set composed of various tumor entities including CNS_NBL, GBM_G34, GBM_MYCN and EPN_RELA cohorts. c. tSNE analysis of 84 institutionally diagnosed cPNET (all black spots) revealed distribution their epigenetic profiles among the four reference tumor sets including CNS_NBL (n = 20), GBM_G34 (n = 22), GBM_MYCN (n = 18) and EPN_RELA (n = 24). d. Survival analysis for CNS-PNET cohort shows that both overall survival (OS) and progression-free survival (PFS) were significantly better for patients harboring tumors with CNS_NBL molecular signature (black lines), in comparison to GBM_G34 (red lines), GBM_MYCN (orange lines) and EPN_RELA (green lines)

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