Table 1 Summary of neuropathology findings
Tau pathology | |
Depths of cortical sulci, perivascular neuronal, astrocytic, neuritic | frontal +++ temporal ++ parietal, occipital - |
Prominent superficial neocortical layers neuronal, astrocytic, neuritic | temporal +++ insular +++ frontal + parietal, occipital - |
Hippocampus neuronal | CA2, CA4 +++ CA3 ++ DG + CA1 sclerosis (astrocytic) + |
Amygdala neuronal, neuritic | +++ |
Striatum, Lentiform nuclei neuronal, neuritic | + |
Thalamus neuronal, neuritic | + |
Hypothalamus incl. Mammillary body neuronal, neuritic | +++ |
Midbrain neuronal, neuritic | substantia nigra +++ median raphe +++ tectum ++ |
Pons | locus coeruleus + abducens nucleus + |
Medulla | – |
Cerebellum | – |
Subpial & periventricular ARTAG | present |
Ghost tangles | CA1, entorhinal, superficial temporal, amygdala |
pTDP-43 pathology NCI, neuritic | amygdala ++ hippocampus + superficial temporal ++ depths of frontal sulci + |
Other pathology | |
Vascular disease, arteriolosclerosis Vascular disease, atherosclerosis | basal ganglia +++ subcortical white matter +++ basal vessels + |
Beta-A4 (amyloid) | Thaal 4 (A3) |
CERAD score | C2 |
Alpha-synuclein | absent |
Diagnosis | CTE Stage III AD-NC (A3, B2, C2) |