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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Fig. 3

Ultrastructural analysis of muscles from NebY2303H,Y935X mice confirmed nemaline bodies, tubular aggregates and pleomorphic mitochondria. a-c Electron microscopic images showing nemaline bodies (white arrowheads) and tubular aggregates (yellow arrowheads) from a 9-month-old male mouse. d-f Nemaline bodies originating from the Z disc identified in 8–12-month-old female mice. g-i Large intermyofibrillar aggregates of mitochondria were seen in all the muscles studied, with notable variation in mitochondrial size within the aggregates

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