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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

Fig. 4

(a - c) Representative images of superior temporal cortex sections of APP V717I mutation carrier labelled with pan-Aβ (4G8, a) antibodies, demonstrate strong labeling of parenchymal and vascular amyloid deposits. Vascular deposits also showed strong staining with Aβ1–42 specific antibodies (12F4, b) and Aβ1–40 specific antibodies (13.1.1, c). Parenchymal amyloid deposits demonstrated strong Aβ1–42 positivity (12F4, b), while being scarcely labelled with Aβ1–40 specific antibodies (13.1.1, c). Vascular amyloid in two SAD cases with different APOE genotype (ɛ3/ɛ3 (d-f) and ɛ4/ɛ4 (g-i)), showed a similar staining pattern with strong positivity for pan-Aβ antibodies (4G8, d, g), as well as Aβ1–42 (e, h) and Aβ1− 40 specific antibodies (f, i). Parenchymal amyloid in SAD cases were highlighted with pan-Aβ (d, g) and Aβ1–42 specific antibodies (e, h), and showed some reactivity with Aβ1–40 specific antibodies (f, i). Overview images (scale bar = 100 μm)

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