Fig. 1From: Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease(a) Representative chromatogram of Sanger-sequencing revealed a guanine-to-adenine single nucleotide substitution at codon 717 of APP, resulting in a Valine to Isoleucine amino acid change in the ADAD patient (APP NM_000484.3 c2149G > A pVal717Ile). (b, c) Representative gross images of formalin-fixed left hemibrain. (d - f) Representative overview (scale bar = 2000 μm) and high magnification (insert, scale bar = 50 μm) images of H&E stained sections reveal neuron loss, astrogliosis and numerous neuritic plaques (d), superficial spongiosis (e), as well as substantial amyloid angiopathy of superficial cortical and leptomeningeal vessels (f)Back to article page