Skip to main content


Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

Fig. 1

(a) Representative chromatogram of Sanger-sequencing revealed a guanine-to-adenine single nucleotide substitution at codon 717 of APP, resulting in a Valine to Isoleucine amino acid change in the ADAD patient (APP NM_000484.3 c2149G > A pVal717Ile). (b, c) Representative gross images of formalin-fixed left hemibrain. (d - f) Representative overview (scale bar = 2000 μm) and high magnification (insert, scale bar = 50 μm) images of H&E stained sections reveal neuron loss, astrogliosis and numerous neuritic plaques (d), superficial spongiosis (e), as well as substantial amyloid angiopathy of superficial cortical and leptomeningeal vessels (f)

Back to article page