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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

Fig. 1

Localization of TTBK1 and pCRMP2 in the pyramidal neurons of the EC and CA1–3 hippocampal regions in early AD brains. The human brain specimens are listed in Table 1. a Deparaffinized human brain sections (8 μm in thickness) containing the EC layer II and CA1 hippocampal regions from patients in Braak I-IV were DAB immunostained for TTBK1 and counterstained with hematoxylin. Top panel: EC regions, bottom panel: CA1 region. Scale bar = 20 μm. b Immunofluorescence of Braak II EC brain sections with AT8 (pSer202/205 tau, green), TTBK1 (red) and Dapi (blue). Scale bar = 10 μm. c DAB immunostaining with 3F4 (pCRMP2) in the EC layer II and CA1 hippocampal regions from patients in Braak I-IV. Scale bar = 20 μm. d Co-localization of 3F4 (pCRMP2) and pSer422 Tau in the CA1 region of Braak I brain sections (indicated by *). Scale bar = 40 μm

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