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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma

Fig. 4

Genetic and morphologic spatiotemporal evolution model. Tumors are schematically shown as circles filled with cells of various morphologies. The initial gliosarcoma is shown in light blue color on the left, adjacent to a box representing its genetic composition of core clonal mutations on the left, and subclonal mutations on the right. The genetic drift is shown on the vertical axis for the closely related intraneural secondary/recurrent foci, and on the horizontal axis for the more divergent lung metastasis. Additional mutations are indicated in the corresponding tumor boxes, whereas the 4-gene core signature is common to all tumors. GBM, glioblastoma

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