Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma

Fig. 2

Morphologic variability of glioblastoma diagnosed in all five tumors. a H&E, GFAP immunolabeling and reticulin special staining show the biphasic pattern of gliosarcoma in the initial frontotemporal mass: the glial component (right upper corner) expresses GFAP and lacks pericellular reticulin deposition, whereas the sarcomatous component (left lower corner) shows opposite phenotype. b Ependymomatous and epithelioid morphology of the frontal and temporal recurrent tumors from the 2nd resection, respectively. Note opposite GFAP labeling patterns with perivascular tumor cell arrangement in the frontal mass (vessels indicated with green arrows), NHERF1 dot-like microlumen labeling in the frontal mass and membranous staining in the temporal mass, high Ki-67 proliferation in the frontal mass, and very focal Cam5.2 cytokeratin staining in the temporal mass. c Resection H&E of the cerebellar mass shows a homogenous glial component, calcifications (black arrow) and damaged vessels obstructed by fibrin thrombi and with invasion of neoplastic cells (blue arrow). d The lung biopsy H&E shows fibrillary areas (inset) with necrosis (black arrow), and pleomorphic areas with brisk mitotic activity (red arrow) and high Ki-67 proliferation index. GFAP diffusely labels the entire tumor

Back to article page