Fig. 3

Seed concentration (LogSD₅₀/mg brain) determinations of 3R, 3R/4R, 4R, and immunohistochemically (IHC) tau-negative brain homogenates by K12 RT-QuIC. Points represent logSD₅₀/mg brain values calculated for a dilution series with a brain homogenate with 8 replicate reactions at each dilution. Error bars represent the standard error of logSD₅₀/mg brain determined by the equation described in Methods. Vertical dotted lines represent mean logSD₅₀/mg brain values across the designated brain homogenate types. PiD, Pick disease; sAD, sporadic AD; fAD, familial AD; CTE, chronic traumatic encephalopathy; PART, primary age-related tauopathy; PSP, progressive supranuclear palsy; CBD, corticobasal degeneration; AGD, argyrophilic grain disease; IVS10 + 3G > A FTDP, frontotemporal dementia with parkinsonism; MSA, multiple system atrophy; PD, Parkinson’s disease; DLBD, diffuse Lewy body dementia; FTLD-TDP43, frontotemporal lobar degeneration with TDP43 protein; ALS, amyotrophic lateral sclerosis; SC, senile change; CVD, cerebrovascular disease