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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

Fig. 1

Comparison of the K12 tau RT-QuIC assay described in this work with the other three currently available tau RT-QuIC assays. Fibril structures were taken from PDB files originally published in [14,15,16, 36]. Cysteines in the canonical tau sequences were mutated to serines (*) or alanine (★) for recombinant tau fragments used in tau RT-QuIC assays. The 3R, AD, and 4R RT-QuIC assays mentioned in this figure have been described previously [21, 23, 27, 29]

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Acta Neuropathologica Communications

ISSN: 2051-5960

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