Skip to main content

Table 2 Demographic and cognitive characteristics of the PSP patients and healthy controls from the “PiPPIN” regional epidemiological study

From: Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity

 

PSP patients (n = 31)

PSP-RS (n = 22)

Variant PSP (n = 9)

Controls (PiPPIN) (n = 60)

p-value Control – PSP

Age at testing

 Mean ± SD

73.3 ± 7.7

71.02 ± 7.3

79.9 ± 5.6

71.4 ± 6.0

n.s.a

 Number (%) of males

19 (61%)

14 (63%)

5 (56%)

30 (50%)

n.s.b

Interval to death (year)

 Mean ± SD

1.8 ± 0.9

2.2 ± 0.8

1.8 ± 0.8

 PSPRS

n = 23

n = 19

n = 3

  

 Mean ± SD

48.9 ± 14.1

47.9 ± 14.1

55 ± 15.1

0.32 ± 0.99

t45 = 17.2, p = 2.2e− 21

ACER

 Mean ± SD

64.2 ± 16.0

65.0 ± 15.0

62.4 ± 19.2

95.7 ± 4.4

t89 = 14.3, p = 9.5e− 25

 CBI-R

n = 24

n = 17

n = 7

  

 Mean ± SD

84.5 ± 52.7

83.6 ± 52.1

86.4 ± 52.7

6.8 ± 7.3

t82 = 11.3, p = 2.6e− 18

MMSE

 Mean ± SD

21.9 ± 4.8

22.3 ± 4.4

21 ± 5.8

29.4 ± 0.9

t89 = − 11.6, p = 1.4e− 19

  1. For PSPRS and CBI-R the n above the mean indicates the number of patients from which data was available. The controls were healthy, age and sex-matched controls from a regional population cohort, PiPPIN [17]. PSP progressive supranuclear palsy, PSP-RS PSP Richardson’s syndrome, PiPPIN “Pick’s disease and progressive supranuclear palsy prevalence and incidence study” [17], PSPRS PSP rating scale, ACER revised Addenbrooke’s cognitive examination, CBI-R revised Cambridge Behavioural Inventory, MMSE Mini Mental State Examination, SD standard deviation, n.s. not significant, p > 0.05, by a Student’s t-test or b Fischer’s exact test. Subscript to t is degrees of freedom. Uncorrected p-values