Fig. 3

CD8+ T cell density is significantly higher in the CP stroma of progressive MS patients relative to that of controls. a Representative images of the progressive MS and control CP immunolabeled with CD4 (green), CD8 (red) and UEA I (white). White arrows point to CD4+ T cells, while white arrowheads point to CD8+ T cells. b Density of CP CD4+ and CD8+ T cells in the CP of control and progressive MS patients (Wilcoxon rank sum test). Scale bars are 100 μm. c Representative image of a CD4+ T cell (green) and a CD8+ T cell (red) in close contact with an APC (MHCII+, white). Maximum projection is accompanied by the orthogonal views. Scale bar is 10 μm. PMS: progressive MS