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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

Fig. 2

T cell density is higher in the CP stroma of progressive MS patients than in the control CP, and they interact with APCs. a Representative images of the control and progressive MS CP immunolabeled with CD3 and collagen IV. White arrowheads point to stromal CD3+ T cells. Scale bars are 100 μm. b Density of CP T cells in the CP of control and progressive MS cases (Welch Two Sample t-test). c Density of CP T cells in the different CP compartments (Wilcoxon rank sum test). d Representative image of a T cell (CD3+, green) in close contact with an APC (MHCII+, red); vessels are visualized with UEA I (white). Maximum projection is accompanied by the orthogonal views. Scale bar is 10 μm. e Absolute density of T cells in close contact with MHCII+ APCs in the CP of control and progressive MS patients, calculated by applying the percentage of T cells that were interacting with APCs to the total density of T cells in their respective samples (Welch Two Sample t-test). f Percentage of T cells interacting with APCs in the CP of control and progressive MS patients, defined as the CP T cells located directly adjacent to MHCII+ cells (Welch Two Sample t-test). g Lack of correlation between interacting T cells and the total CP T cells in each sample (Pearson’s correlation). PMS: progressive MS

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