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Table 2 Affinity determination of 7G6 antibody to wild type and P301S mutant tau protein

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Antigen

ka(1/Ms)

kd(1/s)

KD (M)

Wild type tau

1.65 × 106

6.10 × 10− 5

3.69 × 10− 11

P301S tau

6.82 × 105

3.06 × 10− 4

4.48 × 10− 10