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Table 2 Affinity determination of 7G6 antibody to wild type and P301S mutant tau protein

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Antigenka(1/Ms)kd(1/s)KD (M)
Wild type tau1.65 × 1066.10 × 10− 53.69 × 10− 11
P301S tau6.82 × 1053.06 × 10− 44.48 × 10− 10