From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease
Antigen
ka(1/Ms)
kd(1/s)
KD (M)
Wild type tau
1.65 × 106
6.10 × 10− 5
3.69 × 10− 11
P301S tau
6.82 × 105
3.06 × 10− 4
4.48 × 10− 10