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Table 1 Affinity determination of 7G6 and E2814 antibodies to wild type tau protein

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Antibody

ka(1/Ms)

kd(1/s)

KD (M)

7G6 (mouse)

3.11 × 106

1.95 × 10−4

6.36 × 10−11

E2814 (human)

3.50 × 106

3.07 × 10− 4

8.81 × 10− 11