From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease
Antibody
ka(1/Ms)
kd(1/s)
KD (M)
7G6 (mouse)
3.11 × 106
1.95 × 10−4
6.36 × 10−11
E2814 (human)
3.50 × 106
3.07 × 10− 4
8.81 × 10− 11