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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Fig. 9

Size exclusion chromatography of tauopathy brain samples. Human brain homogenates from AD (upper panels) or PSP (lower panels) patients were loaded onto a Superdex 200 Increase GL size exclusion column in PBS and 1 mL fractions were collected. Samples from each fraction were resolved by SDS-PAGE and tau proteins were detected by western blotting using antibodies raised against two different parts of the full length protein: HT7 (0.2 μg/mL) or 7G6 (0.5 μg/mL) as indicated in the left or right panels, respectively. Images shown are representative from four different AD and six PSP brains

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