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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Fig. 8

LC/MS analysis of tau peptide abundance in the insoluble fraction from human tauopathy brain. Insoluble fractions from AD (n = 3), PSP (n = 4) and control (n = 2) brain samples were prepared and digested with Lys-c and trypsin. Tryptic peptides were identified and quantified by LC/MS. The standardised abundance for each tau peptide was calculated (see Materials and Methods) and compared between AD, PSP and control brain samples. Peptides showing significant change between PSP and AD are plotted. Error bars for AD and PSP represent standard deviation

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