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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Fig. 3

Immunohistochemical staining of tauopathy sections with E2814. a-c: Frontal cortex from AD brain sections stained with 0.5 μg/mL E2814 showing robust labelling of neurofibrillary tangles (arrows). Nuclei stained in blue (quad arrow); d, e: Control staining of AD brain sections with human IgG also at 0.5 μg/mL. f-h,j,k: Frontal cortex from a PSP patient stained with E2814 (0.2 μg/mL) showing widespread staining of neurofibrillary tangles (arrows) and glial inclusions, including tufted astrocytes (G,H; arrowheads) and oligodendroglial coiled body (k; arrow). l: Control staining of a PSP section with human IgG (0.33 μg/mL). Non-specific brown colouration is due to lipofuscin. Nuclei are stained in blue (quad arrows); m,n: Hippocampus from a PiD patient stained with E2814 (0.2 μg/mL) showing strong staining of Pick bodies (arrows). p: Control staining of PiD brain section with human IgG (0.33 μg/mL). Nuclei are stained in blue (quad arrows). Scale bars = 50 μm

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