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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

Fig. 6

Characterization of motor behavior following unilateral striatal cholinergic ablation in R6/2 and WT mice. (a) Time spent at rest and (b) on rapid movements during a one-hour open field session demonstrating a decrease in spontaneous voluntary locomotor activity over time in R6/2 mice with no significant effect of anti-ChAT- or Rabbit-IgG-saporin injections. (c) Cylinder test assessing limb use asymmetry shows no effect of saporin injection on paw preference. (d) Evaluation of dystonia shows an increase in limb clasping at 6 wks in anti-ChAT saporin treated R6/2 mice compared to control-saporin treated R6/2 mice (p = 0.04). A 3-way non-parametric ANOVA was applied to each data set, followed by a post hoc Bonferroni correction; *p < 0.05. For all panels of Fig. 6, WT Rabbit-IgG-saporin: n = 9, WT anti-ChAT-saporin: n = 10, R6/2 Rabbit-IgG-saporin: n = 12, R6/2 anti-ChAT-saporin: n = 11

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