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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

Fig. 5

Unbiased stereological assessment of striatal cholinergic interneuron number 7 wks after intrastriatal injection of anti-ChAT-saporin immunotoxin or Rabbit IgG-saporin (control). ChAT+ neuron numbers were significantly reduced in both R6/2 (p = 0.0002) and WT mice (p = 0.0003) receiving cholinergic specific toxin compared to control saporin. The reduction in ChAT+ neurons was more pronounced in R6/2 compared to WT mice following exposure to anti-ChAT-saporin (p = 0.0004). A two-way between subject ANOVA was applied to the data, followed by a Tukey HSD post hoc test; *** p < 0.001. WT Rabbit IgG-saporin: n = 3; WT anti-ChAT-saporin: n = 3; R6/2 Rabbit IgG-saporin: n = 3; R6/2 anti-ChAT-saporin: n = 5

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