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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

Fig. 4

Cholinergic interneuron distribution in representative striatal sections of R6/2 mce 7 wks after intrastriatal injection of either anti-ChAT-saporin immunotoxin or Rabbit IgG-saporin (control). (a, d) Contours demonstrating the location of ChAT+ profiles in coronal sections of neostriatum. (b, c, e, f) Photomicrographs of corresponding sections immunohistochemically stained for ChAT and Nissl after treatment with either Rabbit IgG-saporin (b, 4X; c, 20X) or anti-ChAT-saporin (e, 4X; f, 20X). Arrowheads demonstrate ChAT+ striatal neurons. Stippled contours indicate the hemosiderin artifact from the injection site. Squares in (b) and (e) represent the area magnified in (c) and (f) respectively. Scale bars: A, B, D, E = 500 μm, C, F = 100 μm. Abbreviations: L.V. = Lateral Ventricle, Str = Striatum

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