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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

Fig. 2

Characterization of motor behavior following unilateral PF lesions in R6/2 and WT mice. Time spent at rest (a) or moving rapidly (b) during a one-hour open field session demonstrating a transient decrease in rest time at 6 wks in R6/2 mice following PF lesions compared to sham-lesions (p = 0.01), that is not sustained at later time-points. (c) The cylinder test assessing voluntary paw reaching motor behaviour shows a persistent decrease in contralateral limb use in both WT and R6/2 mice after PF lesions (6 wks p = 0.00004, 9 wks p = 0.00004, 11 wks p = 0.00008). (d) A significant increase in dystonic clasping is noted in PF lesioned R6/2 compared to sham treated R6/2 mice at 6 wks (p = 0.00008). A 3-way non-parametric ANOVA was applied to each data set, followed by a Bonferroni post hoc correction; *p < 0.05, ***p < 0.001. For Fig. 2 a-d: WT sham: n = 18, WT lesion: n = 17, R6/2 sham: n = 15, R6/2 lesion: n = 22

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