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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Three-dimensional vascular microenvironment landscape in human glioblastoma

Fig. 2

Volumetric increase of GBM vasculature and heterogeneity is due to increased calibers and primary branching. a Creation of COL-IV isosurfaces in normal CTX and GBM. b Volumetric surface increases in GBM. c Measurements of diameter of COL-IV+ vessels in normal CTX (N. CTX) and GBM. d Quantifications of diameters in GBM compared to normal CTX. e, f and g Alpha blending of primary, secondary and tertiary branching points. h Percentage of branching types (single and multiple) in normal CTX and GBM. i Representative image of isosurface rendering and quantification of branching points. j Quantification of primary, secondary and tertiary branching points. k Representative images of branching points in GBM from primary to tertiary (top panel), and looping, intussusception and silent collateral vessels (bottom panel, from left to right respectively). l Quantification of silent collateral BV in normal and GBM

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