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Table 1 Patients’ and tumor characteristics

From: Sporadic multiple meningiomas harbor distinct driver mutations

Patient

Age (years)

Sex

Tumor site

Tumor location

WHO grade

Histologic features

Mutations and allele frequency (%)

MM#1

71

F

Site-A

Infratentorial (L)

1

Transitional

AKT1 p.E17K (33%)

   

Site-B

Petroclival (L)

1

Meningothelial

TRAF7 p.K615N (29%)

MM#2

43

F

Site-A

Convexity (R)

1

Microcystic

NF1 p.F384L (5%)

   

Site-B

Anterior SB (L)

1

Meningothelial/transitional

NF2 p.A325fs (37%)

MM#3

62

M

Site-A

Convexity (R)

2

Atypical

NF2 p.E541* (32%)

   

Site-B

Petrosal (R)

1

Fibrous

None

MM#4

70

F

Site-A

Sphenoid wing (R)

1

Transitional

PIK3CA p.H1047R (36%)

   

Site-B

Pineal region (M)

1

Meningothelial

AKT1 p.E17K (36%)

MM#5

49

F

Site-A

Foramen magnum (M)

1

Meningothelial

POLR2A p.H439del (26%)

   

Site-B

Olfactory groove

1

Meningothelial

SMO p.L412F (40%)

MM#6

53

F

Site-A

Sphenoid wing (R)

1

Transitional

PIK3CA p.H1047R (35%), TRAF7 p.S537F (38%)

   

Site-B

Planum spenoidale (M)

1

Mixed fibrous/meningothelial

PIK3CA p.E545G (30%)

   

Site-C

Convexity (L)

1

Fibrous

PIK3CA p.H1047R (38%)

MM#7

75

F

Site-A

Petroclival (L)

2

Chordoid

AKT1 p.E17K (31%)

   

Site-B

Foramen magnum (M)

2

Transitional

TRAF7 p.R641H (33%)

MM#8

54

F

Site-A

Convexity (L)

1

Meningothelial

TRAF7 p.Q38E (35%)

   

Site-B

Convexity (R)

1

Secretory

TRAF7 p.N520S (41%), KLF4 p.K409Q (40%)

  1. R right, L left, M midline