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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Fig. 6

Neurophysiology of TDP-43 M1-C and PBS M1-C mice. a–d Spontaneous potentials including fibrillation potentials (a), positive sharp waves (b) and fasciculation potentials (c) in the right side of biceps brachialis, tibialis anterior, and gastrocnemius muscles were detected in TDP-43 PFFs M1-C mice at 3 mpi. The frequencies of spontaneous potentials in bilateral biceps brachialis, T10 paraspinals, tibialis anterior, and gastrocnemius muscles muscles were much higher in TDP-43 PFFs M1-C mice compared to PBS M1-C mice at 6 mpi (e). The frequency of abnormal spontaneous activity was developed in a time-dependent manner (f). The amplitude (g) and latency (h) of MUAPs were significantly increased in TDP-43 PFFs M1-C mice compared to PBS M1-C mice at 6 mpi, n = 10 mice/group, P < 0.05. Left-cMEP (L-cMEP) (i, j) and Right-sMEP (R-sMEP) (k, l) were detected in TDP-43 PFFs M1-C mice (i, k) and PBS M1-C mice (j, l). The amplitude of L-cMEP was decreased in TDP-43 PFFs M1-C mice compared to PBS M1-C mice at 6 mpi, n = 10 mice/group, P < 0.001 (m). The CMCT was increased in TDP-43 PFFs M1-C mice compared to PBS M1-C mice at 6 mpi, n = 10 mice/group, P < 0.001 (n). The error bar in all panels represents the Standard Error of Mean (SEM). Data are the mean ± SEM. Statistical analysis was performed using the Student’s t test

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