Fig. 9

Defected mitochondrial ribosome-OXPHOS complexes in R514G mice. a Simplified schematic of mitochondrial ribosomes and OXPHOS complexes. Components of OXPHOS complexes were translated by mitochondria and cytosolic ribosomes. b Heat map of the expression level of the DEGs for mitochondrial ribosomes and OXPHOS complexes in non-transgenic, WT-FUS and R514G-FUS mice along with their mean expression level across all samples (log10(TPM)), and p-value (− log10(p-value)) and fold change (log2(fold change)) in R514G-FUS mice as compared to non-transgenic mice. Positive and negative fold changes are colored red and blue respectively and p-values corresponding to significant q-values < 0.1 are colored in yellow