Fig. 4

R514G-FUS animals show deficits in recognition memory. a R514G mice were assessed for locomotor activity in the open field test. No significant difference in exploratory behaviors were detected between non-transgenic and R514G mice. b A schematic showing the novel object recognition paradigm. c, d R514G mice showed significantly lower time spent with the novel object compared to non-transgenic mice at both 6 and 12 months old, for the short-term, long-term and remote memory probes (p = 0.072 for 12-month-old, remote memory probe; ps < 0.06 for all other probes). For all the tests shown here, there were 5 R514G mice and 6 non-transgenic mice. Orange circles and bars represent R514G mice, and black circles and grey bars represent non-transgenic mice