Fig. 10

Wide-spread brain volume changes and functional connectivity changes in R514G-FUS mice. a Brain structural changes between R514G and the control detected by tensor-based morphometry (p < 0.01, threshold-free cluster enhancement corrected). Wide-spread atrophy (cold color) can be found in the motor, insular, medial prefrontal, piriform, somatosensory and visual cortices and amygdala. Localized brain volume increase (hot color) can be seen mostly in subcortical areas, including ventral pallidum, lateral hypothalamus. Hippocampal CA3, medial geniculate nucleus and paraflocculus. N = 5 per genotype. b Functional connectivity measured by resting-state fMRI. (C) Connectivity matrix of resting-state functional connectivity change between R514G and the control (p < 0.001 uncorrected). Significant connectivity enhancement was seen between the left hippocampal CA2/3 and left visual cortex, and between the right hippocampal CA2/3 and the left diagonal band (n = 4 for non-transgenic, n = 5 for R514G-FUS mice)