Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Table 1 Demographic, pathological and clinical data of CFAS brain donors

Case	Age (y)	Gender	PMI (h)	Brain pH	Braak stage	CERAD^a	Thal Phase	CAA	Dementia¹at death	Cause of death²
C1	87	F	60	6.1	II	None	1	No	No	Depressive episode, unspecified
C2	92	M	33	6.8	II	None	2	Yes	Yes	Chronic ischaemic heart disease
C3	74	M	N/A	6.3	II	Moderate	2	No	No	Acute myocardial infarction
C4	75	M	29	7.3	0	Mild	3	Yes	No	Acute myocardial infarction
C5	73	F	20	6.5	0	None	0	No	No	Amyloidosis
C6	78	F	17	6.9	I	None	1	No	No	Pulmonary embolism
D1	73	M	104	6.2	II	None	0	Yes	No	Cellulitis, unspecified
D2	76	M	16	6.6	II	Moderate	2	Yes	No	Chronic ischaemic heart disease
D3	75	F	5	6.3	I	None	2	No	No	Acute myocardial infarction
D4	73	M	23	6.9	I	None	1	Yes	No	Interstitial pulmonary disease with fibrosis
D5	84	F	12	7.3	II	None	3	Yes	No	Chronic ischaemic heart disease
D6	91	M	36	6.4	II	None	0	Yes	No	Unspecified diabetes mellitus without complications

C, control; CFAS, Cognitive Function and Ageing Study; D, diabetic (type 2 diabetes mellitus); F, female; h, hour; M, male; PMI, post-mortem interval; y, year; CAA, cerebral amyloid angiopathy present or absent
^aCERAD maximum neuritic plaque score
¹Dementia status at death
²Cause of death as recorded from death certification data

ISSN: 2051-5960