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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Fig. 6

Loss of cholinergic innervation selectively increases Aβ40-positive CAA in the hippocampus of TetO-APP mice. a–h Photomicrographs of hippocampal (a and b) and cortical tissues (c and d) of TetO-APP mice stained with antibodies against human Aβ40 (ad, left panels) and Aβ42 staining (ad, right panels). Tissues from control animals are shown in the upper panels and saporin-treated tissues are shown in the lower panels. Arrowheads show plaques and asterisks show CAA-positive vessels. e–h Quantification of % area covered by Aβ40 (e and g) and Aβ42-positive (f and h) plaques and blood vessels in the hippocampus (e and f) and cortex (g and h) of TetO-APPSweInd mice, n = 6–7/group. i–l Photomicrographs of laminin staining in the hippocampus (i) and cortex (j) of control (upper panels) and saporin-treated mice (lower panels). k Histogram showing quantification of laminin density in control and saporin-treated mice. n = 3–5/group. Scale bars = 100 μm. **p < 0.01

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