Fig. 4

Radiographic tumor size change over time, with subclassification based on first post-RT MRI response. a, b Tumor size change across serial MRIs is demonstrated for all patients in the cohort with available imaging data (n = 22). Each dot represents a unique MRI time point, illustrating percent change in bi-dimensional (AP × TR) tumor size from baseline (diagnostic) MRI (y-axis) versus days post-completion of radiotherapy (x-axis). Individual patients’ imaging courses over time are illustrated by lines connecting these dots, which are color-coded based on radiographic response on first post-RT MRI (PD [yellow], SD [purple], PR [green]) c Distribution of histone mutation status (H3.3 [red], H3.1 [blue], or WT [dark green]) across the three post-RT imaging response groups