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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets

Fig. 3

Representative T2 FLAIR, Post-contrast T1 (+ C), and Diffusion-weighted (diff) sequences of diagnostic and first post-radiotherapy (post-RT) MRIs from patients within the three radiographic response groups. a Imaging from patient #23 (overall survival [OS]: 24 months) whose tumor exhibited a partial response (PR) on first post-RT MRI, with no associated contrast enhancement, necrosis, or diffusion restriction. b Imaging from patient #21 (OS: 11 months) whose tumor exhibited stable disease (SD) on first post-RT MRI, with increasing necrosis (*) and enhancement, but similar diffusion restriction along enhancing regions (arrowheads). c Imaging from patient #10 (OS: 5 months) whose tumor exhibited progressive disease (PD) on first post-RT MRI, with associated increased necrosis (*), enhancement (arrows), and diffusion restriction (arrowheads). Areas of diffusion restriction were confirmed on apparent diffusivity maps

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