Fig. 1

Individual genomic profiles of the DIPG tumors in our cohort with corresponding key clinical information. Each patient is represented by a vertical column, with respective color-coding (defined by the key) indicating histone mutation status (H3.3, H3.1, or wild-type [WT]), radiographic response on first post-RT MRI (PR partial response; SD stable disease; PD progressive disease and NA, if lacking imaging data), presence of distant tumor spread and/or metastatic disease at autopsy, presence of necrosis on diagnostic MRI, and presence of mutations in genes with known clinical relevance to DIPG