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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Fig. 8

Graphical summary. The proposed dual mode of repair of astrocyte-depleted experimental ODS lesions in the striatum is shown. The initial parenchymal response is depicted on the right and marked by pink numbers. NG2-positive oligodendrocyte precursor cells (OPCs) are activated (1) and migrate into the lesion center (2), where they proliferate and repopulate the lesion. In the absence of functional astrocytes, OPCs further differentiate to BCAS1-positive pre-myelinating oligodendrocytes with a dysfunctional morphology (3). Most of those cells fail to undergo further maturation and enter apoptosis (4). After the initial repopulation of the lesion with OPCs, the SVZ-derived response (shown on the left in blue) takes place. SVZ-derived oligodendroglial progenitor cells are formed by neural stem cells located close to the third ventricle and migrate towards the lesion (1). At the lesion border, they differentiate into fully mature myelinating oligodendrocytes in the presence of pro-myelinating astrocytic factors (2-4)

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