Fig. 6

SVZ-derived lesion repair of striatal ODS lesions. a Representative microphotographs of the SVZ stained with anti-nestin antibodies at different time points (nestin = brown; nuclei = blue); Original magnification × 400, scale bar represents 50 µm. b Quantification of Ki67+ proliferating cells in the SVZ at different time points after ODS lesion induction. Immunopositive cells per mm SVZ length are plotted (one dot represents one animal, mean ± SEM, one-way ANOVA and Tukey’s multiple comparison, *p < 0.05). c Immunofluorescence double labeling with anti-PDGFRα and anti-nestin antibodies of perilesional and lesional OPCs at 7 dpc (PDGFRα = white, nestin = purple, DAPI = blue, magnification × 400, scale bar represents 10 µm). d Quantification of PDGFRα+ cells with and without nestin immunoreactivity at different time points inside the lesion. Black bars = nestin+ cells, white bars = nestin⁻ cells (mean ± SEM, two-way ANOVA and Tukey’s multiple comparison, *p < 0.05)