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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Fig. 6

SVZ-derived lesion repair of striatal ODS lesions. a Representative microphotographs of the SVZ stained with anti-nestin antibodies at different time points (nestin = brown; nuclei = blue); Original magnification × 400, scale bar represents 50 µm. b Quantification of Ki67+ proliferating cells in the SVZ at different time points after ODS lesion induction. Immunopositive cells per mm SVZ length are plotted (one dot represents one animal, mean ± SEM, one-way ANOVA and Tukey’s multiple comparison, *p < 0.05). c Immunofluorescence double labeling with anti-PDGFRα and anti-nestin antibodies of perilesional and lesional OPCs at 7 dpc (PDGFRα = white, nestin = purple, DAPI = blue, magnification × 400, scale bar represents 10 µm). d Quantification of PDGFRα+ cells with and without nestin immunoreactivity at different time points inside the lesion. Black bars = nestin+ cells, white bars = nestin cells (mean ± SEM, two-way ANOVA and Tukey’s multiple comparison, *p < 0.05)

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