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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Fig. 3

Olig2+ oligodendroglia in experimental ODS lesions. a Quantification of Olig2+ cells at different time points in lesion (white) and perilesion (grey) areas, as well as controls (light grey). b Relative Olig2 mRNA expression in the lesion center at 3, 7, 14 and 21 dpc compared to controls. Expression levels are normalized to the mean number of Olig2+ cells at each time point. c Representative pictures of Olig2+ cells (red); nuclei are stained in blue (DAPI). Upper row original magnification × 200, scale bar 100 µm, lower row shows magnifications of the framed areas above, scale bar 20 µm. d Density of NG2/Olig2 double-positive OPCs in ODS lesions. e Quantification of Olig2/Ki67 double-positive proliferating oligodendrocytes in the entire striatum at different time points. If not stated otherwise, one dot = one animal; one-way ANOVA and Tukey’s multiple comparison; mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001)

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