Skip to main content
Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)

Fig. 6

NFTs in the cerebral cortex of aged pinnipeds (case No. 9). Gallyas-Braak staining-positive argyrophilic aggregates were observed in the neuronal somata and neurites in cerebral cortex pyramidal cell layers (a, b). Thioflavin-S staining-positive neurites were observed in cerebral cortex (c). Immunohistochemically, these aggregates were positive for AT8 (d, e) and AT100 (f). GFAP-positive astrocytes (g) and Iba-1-positive microglia (h) were observed in the cerebral cortex. Reactions to AT8 (g, h) are shown in brown, and those to GFAP (g) and Iba-1 (h) in red. Transmission electron microscopy detected bundles of filaments in neuronal soma of aged pinnipeds (arrows, i). Sarkosyl-insoluble filaments with a diameter of approximately 10 nm in the cerebral cortex of aged pinnipeds (j). AT8-positive hp-tau aggregates were observed in MAP2-positive neurons (k), but not in GFAP-positive astrocytes (l). Some AT8-positive hp-tau aggregates were observed in Olig2-positive oligodendrocytes (arrows, m) and Iba-1-positive microglia (arrow, n). Reactions to AT8 (k-n) are shown in red, and those to MAP2 (k), GFAP (l), Olig2 (m), and Iba-1 (n) in green. Scale bars: 100 μm (a, d); 50 μm (b, eh); 2 μm (i); 50 nm (j); 10 μm (c, kn)

Back to article page