Fig. 5
From: The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
Retinal venules of AppNL-G-F mice have reduced diameters. a, b Retinal vasculature was analyzed at 3 and 18 months of age. Quantification of the density of the vascular network (a) and its branching complexity (b) shows no differences according to genotype. c Retinal venular diameters are reduced in 18-month-old AppNL-G-F mice. Two-way ANOVA with Sidak’s multiple comparison’s test (F1,25 = 3.807 for the effect of genotype, p = 0.0235); n = 7 for 3–6 months, n = 7–8 for 18 months. d No differences are seen in retinal arteriolar diameters. e–f Representative images of isolectin B4-labeled retinal flatmounts of 18-month-old WT (e) and AppNL-G-F (f) mice. e′–f′ Magnification of the region of interest in which vessel analysis was performed. Arrows indicate retinal venules with a reduced diameter. Scalebar: 1000 µm. Data are depicted as mean ± SEM. A = artery, V = vein