Fig. 1

Altered gene expression profiles of microglia isolated from mouse models of neurodegenerative diseases. a Schematic overview of gene expression analysis of microglia isolated from mouse models of different neurodegenerative diseases. b Timeline of the phenotype, pathology, and sampling for each mouse model. Venn diagram displaying the numbers of significantly upregulated (c) and downregulated (d) genes among each comparison between neurodegenerative models and controls: 3318 deregulated genes (1366 upregulated and 1952 downregulated) in App^{NL-G-F/NL-G-F} microglia (n = 4 for each genotype), 2631 deregulated genes (1070 upregulated and 1561 downregulated) in rTg4510 microglia (n = 3 for each genotype), and 3106 deregulated genes (1881 upregulated and 1225 downregulated) in SOD1^G93A microglia (n = 4 for each genotype) (q < 0.05, |FC| > 1.5, TPM > 5). e Principal component analysis of gene expression profiles of microglia isolated from neurodegenerative disease models and their controls. WT, wild-type; Ctrl, control