Fig. 5

Deficit and recovery trajectories of behavioural and magnetic resonance imaging (MRI) markers post-concussion. Relative changes of behavioural and MRI metrics of concussed cohorts relative to the sham cohorts (horizontal black dotted line through 0). Behavioural measurements (NSS and TI) scaled as t-statistics of the corresponding CON versus sham comparison. MRI biomarkers (JI, FA, NDI, ODI, KCC, and stim-fMRI) scaled as whole-brain averaged t-statistics of the corresponding CON vesus sham comparison; whole-brain t-statistics were used as a biomarker proxy that incorporated both extents and degrees of change. NSS = Neuro Severity Score, TI = Thigmotaxis Index, JI = Jacobian Index, FA = Fractional Anisotropy, NDI = Neurite Density Index, ODI = Orientation Dispersion Index, KCC = Kendall’s Coefficient of Concordance (resting-state functional Magnetic Resonance Imaging Regional Homogeneity), and stim-fMRI (stimulus-evoked functional Magnetic Resonance Imaging). An alternative version of figure separating behavioural and MRI changes can be found in Supplementary data Fig. S4