Table 2 Associations between MAPT haplotypes and risk of CBD
Haplotype | MAPT variant | Haplotype frequency (%) | Association with CBD | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
rs1467967 | rs242557 | rs3785883 | rs2471738 | rs8070723 | rs7521 | CBD patients (N = 230) | Controls (N = 1312) | OR (95% CI) | P value | |
H1b | G | G | G | C | A | A | 20.2 | 16.0 | 1.31 (1.00, 1.72) | 0.049 |
H1c | A | A | G | T | A | G | 15.2 | 11.3 | 1.49 (1.11, 2.00) | 0.009 |
H1d | A | A | G | C | A | A | 10.9 | 7.1 | 1.76 (1.22, 2.52) | 0.002 |
H1e | A | G | G | C | A | A | 7.5 | 9.0 | 0.92 (0.62, 1.36) | 0.66 |
H1f | G | G | A | C | A | A | 0.0 | 1.2 | N/A1 | 0.14 |
H1g | G | A | A | C | A | A | 1.6 | 1.1 | 1.45 (0.53, 3.96) | 0.47 |
H1h | A | G | A | C | A | A | 5.4 | 4.1 | 1.22 (0.72, 2.08) | 0.47 |
H1i | G | A | G | C | A | A | 5.9 | 4.4 | 1.65 (1.01, 2.70) | 0.047 |
H1l | A | G | A | C | A | G | 3.7 | 3.0 | 1.10 (0.61, 1.99) | 0.75 |
H1m | G | A | G | C | A | G | 1.6 | 2.9 | 0.77 (0.36, 1.64) | 0.50 |
H1o | A | A | A | C | A | A | 3.5 | 2.3 | 1.81 (0.93, 3.50) | 0.080 |
H1p | G | G | G | T | A | G | 0.9 | 1.5 | 0.82 (0.28, 2.43) | 0.72 |
H1q | A | A | G | T | A | A | 1.3 | 1.0 | 1.49 (0.57, 3.89) | 0.42 |
H1r | A | G | G | T | A | G | 2.6 | 1.1 | 2.03 (0.83, 4.93) | 0.12 |
H1u | A | A | G | C | A | G | 4.4 | 2.4 | 1.60 (0.87, 2.95) | 0.13 |
H1v | G | G | A | T | A | G | 1.7 | 1.2 | 1.10 (0.40, 3.03) | 0.85 |
H1x | G | A | A | T | A | G | 2.2 | 1.3 | 1.54 (0.64, 3.68) | 0.34 |
H1y | A | A | A | T | A | G | 0.5 | 1.6 | 0.54 (0.15, 1.95) | 0.35 |
H2 | A | G | G | C | G | G | 7.1 | 22.7 | 0.26 (0.18, 0.38) | 2 × 10−12 |