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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

Fig. 4

RGC receptive field classification impacts on dendritic loss. ab Representative confocal images of ON-centre RGCs from WT Control, Tg2576, B6J Control 3xTg-AD and APPNL-G-F with corresponding Imaris reconstructions. Arrows indicate axons. Scale bar 100 µm. ce Sholl analysis of reconstructed ON-centre RGCs comparing single models to show significance. Two-tailed Mann–Whitney U test at each interval distance, *p < 0.05. fg Representative confocal images of OFF-centre RGCs from WT Control, Tg2576, B6J Control, 3xTg-AD and APPNL-G-F with corresponding Imaris reconstructions. Arrows indicate axons. Scale bar 100 µm. hj Sholl analysis of reconstructed OFF-centre RGCs comparing single models to show significance. Two-tailed Mann–Whitney U test at each interval distance, *p < 0.05. Sholl analysis line represents mean of group at each interval, shaded error zones represent ± SEM. WT Control ON: n = 43 cells, WT Control OFF: n = 31 cells (7 male mice) Tg2576 ON: n = 30 cells, Tg2576 OFF: n = 28 cells (8 male mice); B6/J Control ON: n = 56 cells, B6/J Control OFF: n = 58 cells (10 mice, 5 male/5 female); 3xTg-AD ON: n = 69 cells, 3xTg-AD OFF: n = 75 cells (12 mice, 6 male/6 female); APPNL-G-F ON: n = 38 cells, APPNL-G-F OFF: n = 41 cells (6 mice, 3 male/3 female). All mice aged 12 months. WT wildtype

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