Fig. 2
RGC dendritic diameter increases in AD mice. a Representative confocal images of RGC dendrites from WT Control, Tg2576, B6J Control 3xTg-AD and APPNL-G-F. Arrows indicate beading and swelling of dendrites. Scale bar 25 µm. b Dendrite varicosity, assessed by measurement of dendrite diameter. Column Scatterplots: data points represent individual cells and error bars correspond to SD. WT Control: n = 74 cells (7 male mice), Tg2576: n = 58 cells (8 male mice), B6J Control: n = 114 cells (10 mice, 5 male/5 female), 3xTg-AD: n = 144 cells (12 mice, 6 male/6 female) and APPNL-G-F: n = 80 cells (6 mice, 3 male/3 female). All mice aged 12 months. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001