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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development

Fig. 4

Amide I band analysis. A Mean Amide I bands of all plaque spectra from each plaque type, core spectra generated by hierarchial cluster analysis (HCA), and gray matter control spectra. The shoulder around 1628 cm−1 indicates β-sheet protein. B Cutout of mean difference spectra between plaque spectra and their respective surrounding spectra. Note the shift to lower wavenumbers and the increased absorbance around 1620 cm−1. C Visualization of sub-bands of the Amide I in the region 1700–1600 cm−1. The marked local minima indicate bands that are relevant for protein secondary structure. Note the substantial increase of the band around 1628 cm−1 alongside the plaque development sequence. The band around 1693 cm−1 displays little change, whereas the band around 1682 cm−1 increases, and the bands around 1657 cm−1, and 1639 cm−1 decrease

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