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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

Fig. 3

LPO and associated oxidative damage are reduced following administration of D-PUFAs. a and c Series of high-resolution confocal microscopy images obtained at 40 × of SN sections stained for TH+ (blue), human α-syn (red) and 4-HNE or 4-HHE (green). Quantitative assessment of the fluorescence signal of 4-HNE (b) and 4-HHE (d) in the contralateral and ipsilateral rat SN. Values are mean ± SEM of three sections (average of ~ 150 TH+ neurons) per animal. Each group comprised four rats. Scale bar: 20 μm. Content of 8-IsoP in the rat striatum (e) and SN (f). Levels of PGF2α in the rat striatum (g) and SN (h). Each value represents the mean ± SEM of seven animals per group. ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05. Two-way ANOVA followed by Tukey’s post-hoc multiple comparisons test

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