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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Prenatal alcohol exposure is a leading cause of interneuronopathy in humans

Fig. 4

Calretinin immunohistochemistry in the brains of FASD and control at 30 WG. Quantitative analysis of cortical distribution of CR interneurons in each layer showing a predominance in superficial layers in particular layer I in normal brain whereas they were still present in the deeper layers in FASD brain (red arrows) (a), associated with a lower global density in FASD brain compared to normal brain (b). Statistical analysis using Chi square again confirmed that the cortical distributions significantly differed between the control and the FASD cases (c). Cortical distribution of CR interneurons which were still present in the deeper layers in FASD brain (asterisk) (d) compared to control cortical plate in which CR cells were located in superficial layers, in particular layer I (asterisk) (e). CR interneurons were more abundant respectively in GE (f, g) and SVZ (h, i) of the FASD brain compared to control [OM x 20]. Scale bar = 0,18 mm. Inserts within Fig. 4d and e illustrate the bipolar morphology of CR interneurons at an original magnification of 400. CP: cortical plate; CTRL: control cases; GE: ganglionic eminence; FASD: foetal alcohol spectrum disorder; OM: original magnification; SVZ: cortical subventricular zone

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