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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Fig. 3

Brain inflammation in Tg2576 mice is increased by infusion of Tg-blood. a Representative pictures of reactive astrocytosis and microglial activation observed in the hippocampus of different animals. The scale bar represents 300 µm. Image analysis was done to quantify the extent of astrocytosis (b) and microgliosis (c) in different groups. The values correspond to the area stained with GFAP or Iba-1 antibodies per unit of brain area analyzed and are expressed as a percentage (mean ± SEM) (n = 5–6). *P < 0.05; **P < 0.01; ***P < 0.001 based on ANOVA followed by the Tukey’s multiple comparison post hoc test. d Correlation between the extent of amyloid deposition measured by the ThS burden (as shown in Fig. 1d) and GFAP burden in each of the individual animals studied in the groups of Tg2576 untreated or subjected to 1 or 2 transfusions with blood from old Tg2576 or to 2 transfusions with wild type blood

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